BIOL 2421 Microbiology Lecture Review
Immunology
Dr. Weis

1. List and explain the nonspecific body defenses and give examples for each.

2. Know the chemicals, cells, or tissues involved with the first and second line nonspecific body defenses.

3. Complement: know what it is, what it does, 3 pathways, how each pathway is activated, the major steps involved, and the end results of complement activation [fixation].

4. Interferon: know the source, types, and effect

5. Give four ways that microbes can evade the innate (nonspecific) immunity

6. Antibody: know the general structure of an antibody. Know the 5 classes and be able to discuss/describe these antibody classes with regards to structure, location, amount (%), and function/action.

7. List and describe the four possible reactions when Antibody binds to Antigen and relate these reactions to tests that can be used to identify immune responses (see chapter 19)

8. Antigen: Know the two major types. Define foreign antigen and give the two types. Be able to give examples of bacterial antigen that could provoke an immune response. Know which macromolecule classes can act as foreign antigen and classify or list them in order of antigenicity. Define antigenic determinant, epitope, and valence.

9. Explain the concept and importance of memory cells. List the various types and where they arise (source). Explain how they are activated.

10. MHC*HLA: Give the two types, what they are, where they are found, how cells interact with these regions, and their importance to the immune system and transplants (see chap 19).

11. Name four lymphokines, their source and MOA [method of action].

12. Give four ways that microbes evade the specific immune system.

13. Name two aging changes that happen with the immune system.