BIOL 2421 Microbiology           Immune Worksheet (25 points)               Name: ___________

Dr. Weis                       Questions @ 1.5 each unless otherwise specified      Due Date: ________

1a. Draw with labels identifying the major cell parts a representative picture of a

                a. Neutrophil

                b. Macrophage

                c. Eosinophil

                d. Basophil

1b. and also give the unique & different function for each and their % found in normal human blood. (2)

2. Name three first line defenses and pick one to draw and label in detail and give its secretion(s).

3. Name four second line defenses and explain how they each are controlled.

4. Draw a representative picture of a generalized immunoglobulin molecule. Name the five major classes and give the location and function for each of these antibody classes.

5. Name and describe or draw with labeled pictures the four results that could happen with an antibody/antigen reaction.

6. Define MHC*HLA; name the two major classes and explain how each class interacts with specific lymphocytes.

7. Define complement; name the three major pathways for activation and describe the three end results due to these effector actions of complement.

8. Define foreign antigen, give four characteristics of foreign antigen and describe how these characteristics relates to overall immunity and unique immune cell function.

9. Draw with labels identifying major cellular parts, a representative picture of a lymphocyte. Name the three major types of lymphocytes and their unique function, secretion(s), and their effects.

10. Name the lymphocyte receptors for these lymphocytes listed in #9, along with any other important membrane markers and other proteins that make these immune cells unique. Explain how these cells use these to identify self vs. foreign antigen and communicate during an immune response.

11. Properly define the following

                a. apoptosis

                b. immunocompetence

                c. APC

                d. interferon

12. Define hypersensitivity; name the major classes and pick one class and explain it in more detail by giving an example and describing the reactions that occur and the possible end result (sequella).

13. Explain the positive and negative selection processes that happen in the Thymus.

14. Explain how endogenous and exogenous antigen is processed and define and give an example of a super antigen.

15. Name five different cytokines. Give their source and their function/effects at their various targets.

16. Name three different immunodeficiency disorders (1 acquired and two inherited) and five different autoimmune disorders (2 related to HLA, 2 related to autoantibody, 1 related to environmental factors) and explain graft vs. host disease. (2)