HPRS 2201 Pathophysiology Review Sheet: Genetics

1. Define related genetic terms.
2. Discuss DNA location, structure, base pairing rules, how and when replicated, transcription, and translation events.
3. Name and describe all the events of the cell cycle and when problems can occur.
4. Compare and contrast mitosis and meiosis.
5. Know chromosome types, number, structure, and be able to name and discuss general abnormalities in number and structure.
6. Know three specific examples of extra chromosomal disorders and three specific examples of chromosomal deletion disorders.
7. Describe the causes of DNA mutations and be able to list and explain the various types.
8. Name and describe the normal Mendelian Inheritance Patterns. Give three specific examples each of problems related to autosomal dominant, recessive, sex-linked, and multifactoral disorders.
9. Name two epigenic alterations that can lead to changes in gene expression.
10. Name two general mtDNA disorders.
11. Be able to do Punnett Square crosses using the genotype and the resulting phenotypes.
12. Explain the importance of genetic testing and counseling.